Kavala 1st High School is the oldest high school in town and is located in Konstantinidou Poiitou 16 street.
The school was built by the town's Turkish community during the period 1909-1910. Its architecture is a mixture of Neoclassical and Ottoman elements (such as its wooden eaves). Apart from hosting a Turkish school, it also hosted a Greek hospital during the Balkan Wars until 1916. The building was acquired by the Greek state in 1922.