The relief depicts Orpheus' descent to the Underworld to bring his beloved wife Eurydice back to life. On the left, the god Hermes is depicted as Psychopomp (a guide of souls to Hades). He wears short chiton tied in the waist, chlamys pinned at the right arm, endromides (soft boots) and petasos (broad brimmed hat), hanging behind his head. Ιn the center, Eurydice is depicted facing Orpheus. She wears a long chiton and peplos that covers her head. To the right, Orpheus also turns towards Eurydice, extending his right hand towards her. He wears short chitoniskos tied in his waist, chlamys, endromides and alopeke (fox fur cap). He holds his lyre in his left hand.

This Roman relief copies an attic original, probably erected in a public building of the Athenian Agora and dated to the end of the 5th c. BC. In the 16th century, after a mistaken identification of the figures, the three following inscriptions were engraved: ZETVS, ANTIPOE and AMPHION (Zetes, Antiope and Amphion).